Murrayfield hosts a mid-table clash of two ancient rivals on Sunday, with both Scotland and Wales hoping to walk away with their first win of the campaign.
The most pivotal game of the weekend in terms of championship relevance takes place in Dublin, where defending champions Ireland host arch-nemesis France.
A despondent Italian side limps into Twickenham on the back of a sound beating in Rome, with virtually no chance of victory against hosts England.
Two new-look sides face off with expectations guarded but high for each, but Paris is just about the worst place for any team to start their tourney.
Ireland will hope to draw inspiration from dominant performances from their u20 and women’s sides as they march into Rome slightly battered but confident.
Everyone remembers the horrors of Cardiff on England’s last visit. It didn’t just cost the championship, it cost several players spots on the Lions tour.
With so many players now graduating from the u20 programs to senior international level, it’s a surefire way to catch a glimpse of the stars of the future.
It’s not crazy to think this might be the last ever Six Nations ‘A’ international. A sobering thought, one of the negative after-effects of professionalism.
Wales close out a turbulent year against the mighty Bokke, with the crushing heartbreak of defeat against the All Blacks still weighing heavy on the mind.
After a narrow defeat to France at the Stade de France, the Wallabies will be hoping to close out their tour with a win over England at Twickenham.